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When does Cialis (tadalafil) patent protection end? Cialis’s active ingredient is tadalafil, and “when it goes off patent” depends on which kind of protection you mean (a full patent expiry date vs later exclusivities or enforcement tied to specific patents) Patents Listed in the FDA Orange Book Drug Database of Cialis, Tadalafil with information and expiry expiration datesWhere to check the exact patent and expiry date for “Cialis”? To find the exact expiration date you care about, you need the specific patent number (or the patent family) for the jurisdiction in question Jan 7, 2020 · How have patent expirations and exclusivity timelines shaped tadalafil financial performance? Featured snippet answer: Tadalafil’s branded era ended well before today’s generic-dominant market structure in the US and most developed markets May 25, 2026 · Eli Lilly's patent strategy for Cialis relied on multiple overlapping patents that extended market exclusivity well beyond the original compound patent The compound patent (U S Patent No 5,859,006) covered the tadalafil molecule itself and was set to expire in 2017 2 days ago · The drug, primarily known for treating erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), has seen its market exclusivity erode with the expiry of key patents May 25, 2026 · The core compound patent, US 5,859,006 (the '006 patent), was filed in 1994 and covered tadalafil itself as a chemical entity It was set to expire in 2016 but received a pediatric exclusivity extension of six months, pushing the effective expiry to November 2017