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4 years agoJul 17, 2025 · For two weeks, I snapped on a surgical glove and applied a thin layer of Efudex and a vitamin D derivative called Calcipotriene all over my face and chest, once in the morning and once before bed 4:51I started the Tolak cream last Tuesday evening (4 16) and today (4 25) my skin looks no different at all, it's not even dry I know I have sun damage on my face, not 100% sure there are any AK's, but I'm not even a little bit pink anywhere 3 months agoAnother factor to consider is that Efudex doesn’t necessarily show signs of working DURING the treatment The scabbing may not begin developing until a week or so after the last application Along with its needed effects, fluorouracil topical (the active ingredient contained in Efudex) may cause some unwanted effects Although not all of these side effects may occur, if they do occur they may need medical attention Check with your doctor immediatelyif any of the following side effects occur while taking fluorouracil topical:See full list on drugs comThe treatment duration of Efudex cream is twice daily for 2-4 weeks, during which time you should expect to have an erosive reaction causing redness and scabs on the precancerous spots Skin not damaged by UV rays do not typically react to the cream 1:14Feb 24, 2026 · Get clear safety guidance for Efudex, including warnings, precautions, when to seek medical assistance, and how to use it correctly 11 months agoJul 13, 2022 · Hi, I've been using Efudex 5% twice a day for three weeks on one cheek due to AK and an IEC I've had quite a mild reaction - nothing until day 7 and then some slowly reddening AKs some of which now look a bit dried out 7:31