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Mipomersen is defined as an antisense oligonucleotide that inhibits apolipoprotein B synthesis, thereby lowering VLDL and LDL levels It is an FDA-approved medication used for treating homozygous familial hypercholesterolemia and is administered subcutaneously at a dosage of 200 mg weekly Mar 1, 2026 · Mipomersen injection is used together with a proper diet and other medicines to treat high cholesterol levels in patients with homozygous familial hypercholesterolemia (HoFH) Jun 29, 2026 · Mipomersen is a cholesterol-lowering medication It reduces blood levels of "bad" cholesterol, such as low-density lipoprotein (LDL), apolipoprotein-B (apo-B), or non-high-density lipoprotein (non-HDL) Mipomersen is a second-generation antisense oligonucleotide (ASO) that is delivered by subcutaneous injection, which targets mRNA of ApoB, the major protein of LDL-C, and its precursor VLDL Mipomersen is an antisense oligonucleotide targeted to human messenger ribonucleic acid (mRNA) for apo B-100, the principal apolipoprotein of LDL and its metabolic precursor, VLDL Jan 22, 2015 · In this study, we examined the effect of mipomersen on Lp (a) in 4 randomized, double-blind, placebo controlled phase III trials Materials and methods are available in the online-only Data Supplement Mipomersen (INN; trade name Kynamro) is a withdrawn drug that was used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection There is a serious risk of liver damage from this drug and it was only prescribed in the context of a risk management plan Mipomersen injection is used to decrease levels of cholesterol and other fatty substances in the blood in people who have homozygous familial hypercholesterolemia (HoFH; a rare inherited condition that causes very high levels of cholesterol in the blood, increasing the risk of serious heart disease) Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity 398 Mipomersen is an antisense oligonucleotide targeted to human messenger ribonucleic 399 acid (mRNA) for apo B-100, the principal apolipoprotein of LDL and its metabolic 400 precursor, VLDL