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Apr 13, 2026 · The lethal dose of Nembutal, generic name pentobarbital, is about 30 milligrams per liter (mg L) Learn more about the lethal doses of commonly abused drugs How A Lethal Dose Of Nembutal (Pentobarbital) Is Determined Nembutal is a Drug Enforcement Administration (DEA) Schedule II controlled substance Clinical Information Pentobarbital is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties Uses include sedation induction, relief of preoperative anxiety, control of status epilepticus or seizures resulting from meningitis, tetanus, alcohol withdrawal, poisons, chorea, or eclampsia, and induction of coma in the management of cerebral ischemia and increased RATIONALE: Studies evaluating the use of pentobarbital as a prophylactic therapy in severe TBI have shown no significant improvement in outcome, although barbiturates have been shown to successfully reduce ICP The most recent Brain Trauma Foundation Guidelines for the management of severe TBI (4th Ed ) recommend high-dose barbiturate administration for elevated ICP refractory to maximum Feb 1, 2024 · NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume The pH is adjusted to approximately 9 5 with hydrochloric acid and or sodium hydroxide Bernstein JE, Ghanchi H, Kashyap S, et al Pentobarbital coma with therapeutic hypothermia for treatment of refractory intracranial hypertension in traumatic brain injury patients: a single institution experience Mar 30, 2026 · Pentobarbital side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat Pentobarbital may cause serious side effects Call your doctor at once if you have: confusion, agitation, hallucinations; weak or shallow breathing; slow heart rate, weak pulse; or a light-headed feeling, like you might Oct 14, 2025 · A state law shields its source of pentobarbital, the sedative used in lethal injections But documents reviewed by NBC News offer a glimpse into its most recent supply Jan 26, 2026 · Easy-to-read patient leaflet for Pentobarbital Includes indications, proper use, special instructions, precautions, and possible side effects Pentobarbital is a medication used for sedation (pre-anesthesia) before surgery, for short term insomnia treatment, and for emergency control of seizures Common side effects of pentobarbital include slow heart rate (bradycardia), low blood pressure (hypotension), fainting (syncope), nausea, vomiting, constipation, pause in breathing (apnea), slow and shallow breathing (hypoventilation Pentobarbital (US) or pentobarbitone (British and Australian) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies [3] It can also be used for short-term treatment of insomnia but has been largely replaced by the benzodiazepine family of drugs In high doses, pentobarbital causes death by respiratory arrest It is frequently