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Mar 15, 2023 · The interaction between alcohol and Wellbutrin can increase the risk of seizures and other adverse side effects Wellbutrin and alcohol can lead to a lethal overdose depending on several factors, including sex, height and weight, age, and tolerance Aug 20, 2025 · Healthcare professionals generally advise against consuming alcohol while taking bupropion due to the potential for serious interactions Combining alcohol with bupropion carries several notable risks A key concern is an increased risk of seizures In general, you should avoid or limit the use of alcohol while being treated with buPROPion Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you My doctor told me, and the Internet says, that you should limit or not drink alcohol at all while on Wellbutrin Your risk of seizures increases and it lowers the effectiveness of the medication Jun 26, 2023 · It is not safe to mix Wellbutrin and alcohol The National Institute of Health (NIH) notes that alcohol, on its own, acts as a depressant It interferes with the brain’s communication pathways, Dec 13, 2024 · A person should not take bupropion and alcohol together This is because alcohol can intensify the possible side effects associated with bupropion Jun 1, 2026 · The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping Apr 18, 2026 · Cleveland Clinic notes that drinking large amounts of alcohol or quickly stopping sedatives while on bupropion "may increase your risk for a seizure," and that insomnia, jitteriness, and dry mouth from Wellbutrin can worsen on alcohol Jun 4, 2019 · It’s generally best to avoid alcohol while taking Wellbutrin But in some cases, abruptly quitting drinking while taking Wellbutrin can have serious effects on your health May 14, 2024 · It’s best to avoid drinking alcohol while taking bupropion (Wellbutrin SR, Wellbutrin XL) Combining alcohol and bupropion can increase your risk of side effects